Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis

Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended on growth. To systematically review the literature, up to December 2018, conducting a meta-analysis association long-term (> six months) MPH exposure with height, weight and timing puberty. Eighteen studies (ADHD n = 4868) were included in meta-analysis. was associated consistent statistically significant pre-post difference both height (SMD 0.27, 95% CI 0.16-0.38, p < 0.0001) 0.33, 0.22-0.44, Z scores, prominent impact during first 12 months within 24-30 months. No dose, formulation, age drug-naïve condition as clinical moderators found. Data puberty are currently limited. Long-term can result reduction weight. However, effect sizes small possible minimal impact. prospective may help clarify underlying biological drivers specific mediators moderators.